As the movie opens, Debbie is turning 40 but tells everybody she's younger. She runs a small, boutique clothing store that's breaking even financially, while Pete manages a retro-minded indie-music label that's under serious financial strain just as they are trying to launch a new album by Graham Parker. Their money troubles are compounded by Pete's dad Larry (Albert Brooks), who continually hits up his son for cash because he has toddler triplets after an overly successful fertilization treatment with his younger second wife. Debbie has daddy issues as well. Her father (John Lithgow), an emotionally cold, highly successful surgeon, seems to want no part of his daughter's life, even though they meet for lunch occasionally after not talking to each other for a lengthy period of time. All of these people, along with Debbie's trainer, Pete's employees, and salesgirls from Debbie's boutique, arrive at the couple's beautiful home for a birthday party where all the familial wounds are opened.